박중찬 교수
  • 이메일
  •    jpark@hufs.ac.kr
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  • 학력
  •    1986년 서울대학교 미생물학과, 이학사
  •    1988년 서울대학교 미생물학과, 이학석사
  •    1991년 ~ 1995년 미국 Brown 대학교 Bio-Med, 이학박사 (분자면역학 전공)
  • 경력
  •    1989년 ~ 1990년 한국외국어대 미생물학과 조교
  •    1993년 ~ 1995년 Roger Williams Medical Center/Brown University, 연구원
  •    1996년 미국 Harvard 의대, Center for Blood Research, Post-doctoral Research Fellow
  •    1996년 9월 - 현재 한국외대 생명공학과 조교수, 부교수, 교수
  •    2003년 미국 MIT 대학교 방문교수
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  • Research Interests
  •    - Cytokine 발현조절
  •    - Cytokine 발현조절을 통한 면역억제제개발
  •    - 비천연 아미노산의 단백질 삽입기술 개발
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  • 최근 논문
  • - Lee M, Park J., 2006, Regulation of NFAT activation: a potential therapeutic target for immunosuppression, Mol Cells, 22(1):1-7
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  • - Kim, K., Park, C., Yeo, H., Kee, Y., Park, J , and Myung, H.. (2000)
    Implication of exonuclease activity of bacteriophage P2 old protein for lambda exclusion. J. Microbiol. Biotechnol. 10:272-274
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  • - Jin, H.K., Kim, M., Park, C., Park, J ., and Myung, H. (2001)
    Interaction of the bacteriophage P2 Tin protein and bacteriophage T4 gp32 protein inhibits growth of bacteriophage T4. J. Microbiol. Biotechnol . 11: 724-726
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  • - Park, C., Kee, Y., Park, J ., and Myung, H. (2002) A nonisotopic assay method for hepatitis C virus NS5B polymerase . J. Viol. Methods 101: 211-214.
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  • - Lee, M.-O., Kang, H.-J., Kim, Y., Oum, J.-H., and Park, J . (2002)
    Rrepression of FasL expression by retinoic acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T-cells.
    Eur J Biochem . 269(4):1162-70.
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  • - Oum, J.-H., Han, J., Myung, H., Hleb, M., Sharma, S., and Park, J. (2002)
    Molecular mechanism of NFAT family proteins for differential regulation of the IL-2 and TNF- α promoters. Mol. Cells 13, 77-84.
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  • - Bae, S.-J., Oum, J.-H., Sharma, S., Park, J., and Lee, S.-W. (2002)
    In vitro selection of specific RNA inhibitors of NFATc. Biochem. Biophy. Res. Comm . 298: 486-492.
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  • - Han, J., Kim, M., Oum, J.-H., Myung, H., Lee, S.-W., Jeong, S., Sharma, S., and Park, J. (2002)
    RACK-1, a receptor for activated C kinase, interacts with the transcription factor NFAT and represses its transactivation. Mol. Cells 14: 420-424
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  • - Cho, J-S., Lee, Y.J., Shin, K.-S., Jeong, S., Park, J., and Lee, S-W. (2004)
    In vitro selection of specific RNA aptamers for the NFAT DNA binding domain. Mol. Cells 18: 17-23
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  • - Lee, M. and Park, J. (2006) Regulation of NFAT activation: a potential therapeutic target for immunosuppression. Molecules and Cells 22: 1-76
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  • - Lee, D.Y., Chun, J.H., Ha, H.J., Park, J., Kim, B.S., Oh, H.B., and Rhie, G,E. (2009)
    Poly-gamma-d-glutamic acid and protective antigen conjugate vaccines induce functional antibodies against the protective antigen and capsule of Bacillus
    anthracis in guinea-pigs and rabbits. FEMS Immunol. Med. Microbiol. 57:165-172
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  • - Cho, M,H,, Ahn, H.J., Ha, H.J., Park, J., Chun, J.H., Kim, B.S., Oh, H.B., Rhie, G.E. (2009)
    Bacillus anthracis capsule Activates Caspase-1/ICE and Induces Interleukin-1{beta} release from Differentiated THP-1 and Human Monocyte-derived Dendritic
    cells. Infect. Immun. 2009 Sep 8. [Epub ahead of print]
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  • - 김경태·박미영·박중찬. (2009)
    대장균에서 비천연 아미노산의 위치특이적 삽입을 위한 Amber Suppressor tRNA와 Aminoacyl-tRNA Synthetase의Amber Suppression 활성측정시스템 개발.
    미생물학회지 45: 215-221.
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  • - jung, H.J., Shim, J.S., Park,J.,Ha,H.-J.,Kim,J.-H.,Kim,J.-G.,Kim,N.D.,Yoon,J.H.,andKwon,H.J.(2009)
    Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt.
    proteomics-Clinical App.3:423-432
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  • - Kim, K., Park, M.-Y.,and Park,J.(2009)
    Establishment of an in vivo reporter system for the evaluation of amber suppression activity in E. coli.
    Kor. J. Microbial. 45: 215-221.
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  • - Cho, M.H,, Ahn, H.J., Ha, H.J., Park,J.,Chun,J.H.,Kim,B.S.,Oh,H.B.,Rhie,G.E.(2010)
    BacillusanthraciscapsuleActivatesCaspase-1/ICEandInducesInterleukin-1{beta}releasefromDifferentiatedTHP-1andHumanMonocyte-derivedDendriticcells.
    Infect. Immun. 78:387-392
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  • - Jang, J., Jung, K-T., Park, J., Yoo, C-K., and Rhie, G-E. (2011)
    The Vibrio cholera VarS/VarA two-component system controls the expression of virulence proteins through ToxT regulation.
    Microbiology 157: 1466-1473
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  • - Singh, A., Ha, H-J., Park, J., Kim, J.H., and Lee, W.K. (2011) 3,4-disubstituted oxazolidin-2-ones as constrained ceramide analogs with anticancer activities.
    Bioorg. Med. Chem. 19:6174-6181
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  • 특허
  • - 엔에프에이티씨에 특이적으로 결합하는 알엔에이 (RNA specifically binding to NFATc).
    등록일 2005. 1. 18. 등록번호 10-0468388
  • - 3,4-디히드로이소퀴놀리늄유도체및이를포함하는약학조성물
    등록번호: 제10-1018330, 등록일: 2011. 2. 22.
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  • 저서/번역서
  • 1. Brock의 면역학: 23장 분자면역학, 25장 진단미생물학 및 면역학. (2006) 월드사이언스 pp. 761-816.
  • 2. Ha, H-J., Lee, W.R., and Park, J. (2008)
    Chapter 7 Synthetic ceramide analogs for anticancer agents: In Glycolipids; New Research. Editor: Daiki Sasaki. Nova Science Publishers
  • 3. Brock의미생물학: 23장분자면역학, 25장진단미생물학및면역학. (2006) 월드사이언스pp. 761-816.
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